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Act when Alzheimer's disease manifests only mild cognitive impairment may delay or modify the action of neurodegenerative symptoms. The diagnoses also refined with the use of specific biomarkers, which will undoubtedly strengthen the therapy.
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The detection and management of mild cognitive impairment that appears in the early stages of Alzheimer's disease (AD) is one of the issues that currently are considered essential in the fight against this disease. The aim is to intervene to eliminate, delay or modify the action of the disease before it does damage, according to Paul Martin Martinez, director of the Foundation's Scientific Research Center of Neurological Diseases and president, along with Jesus Avila, Biology Centre Molecular Severo Ochoa (CSIC-UAM), Madrid, the Fourth Symposium on Advances in this disease which takes place today at the Alzheimer's Foundation Queen Sofia on the occasion of World Alzheimer's Day, and has the support of Sanofi-Aventis. Martinez referred to the onset of memory lapses that do not impede normal life as the moment in which, according to the scientific community would be appropriate to tackle the disease. In this vein, Ronald Petersen, director of Mayo EA and director of research at the Mayo Clinic in Rochester, Minn. (U.S.), believes that MCI represents a transitional state between the cognitive changes related with age and diagnosis Initial clinical dementia. Identify risks
Recent epidemiological data show that about 16 percent of people between 70 and 89 years are probably slight deficit. Clinical trials have been conducted in this phase, which apparently does not meet the neuropathological criteria of AD have not produced the desired results, as research continues to deepen to specify criteria.
According to Julian Gil Perez, CEO of the Foundation CIEN, currently there are many projects underway to identify potential risk general population. The studies not only focus on the trite and cardiovascular risk factors like hypertension and cholesterol, among others, but that address other elements. "
also referred to areas that have a brighter future and that, in his view, could be summed up in drugs , "with the development and emergence of new substances more effective in five years."
longer term, primarily for application in the clinic, there is still hope in stem cells of the central nervous system.
Support
art clinical diagnostics to achieve concrete and earlier is also necessary to improve detection systems, and differential diagnosis. In the latter field, Martinez Martin has referred to the development of specific biomarkers, such as cerebrospinal fluid proteins, with the support of the PET / MRI "may make a diagnosis of dementia or fronto-temporal Lévy bodies, eg ".
Neuroimaging has been used to differentiate between envejecimeinto deterioration or dementia. Magnetoencephalography distinguishes various components of brain activity in the elderly. It is curious that simulates an old man with features of dementia depression.
The expert has spoken here of the new elements in the use of PET for dementia are capable plotters of signaling by this protein injury. It is one of the most cutting-edge lines and is intended to be subrogate the treatment of disease. "
Henry Engler, Nuclear Medicine Hospital of Uppsala, Sweden, will present one of the new elements of amyloid markers, Pittsburgh Compound B . This compound is a radioactive tracer that enters the brain, is cleared rapidly from parénquina healthy brain and maintained in amyloid plaques, indicating protein loading. "That is progress because it provides first line diagnostics as determines the presence, amount and specific distribution of more specific brain lesions of AD.
Benefits
Perform rapid cognitive screening mandatory for all people they suspect of being in age or at risk is the idea that those responsible for launching the English Confederation of Association of Relatives of Alzheimer Patients and (CEAFA).
"Translation is a preventive diagnosis, and that early also be imposed in the cognitive therapies, as well as drug administration has indicated Marmaneu Henry, president of CEAFA.
pharmacology remains one of the areas increased research interest. New approaches appear with antibodies modulators and inhibitors GSK-3, based on molecular biology and potential ability to change the course of Alzheimer's, and the tests carried out with the tau protein. -------------------------------------------------
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